Background: Intracholecystic papillary neoplasms (ICPN) of the gallbladder are rare epithelial lesions considered precursors to invasive carcinoma. Histologically, they show papillary proliferation of biliary epithelium with variable dysplasia.
Case Presentation: We report the case of an 82-year-old hypertensive woman presenting with right upper quadrant pain triggered by heavy meals. Imaging revealed a lobulated intraluminal mass in the gallbladder fundus suggestive of neoplasia. After multidisciplinary discussion, a laparoscopic cholecystectomy was performed. Histopathology confirmed ICPN with high-grade dysplasia, without invasive foci. Postoperative course was uneventful, and the patient remained asymptomatic at six months.
Conclusion: ICPN is an uncommon but important preinvasive gallbladder lesion. Early recognition and complete surgical resection result in excellent prognosis, highlighting the importance of histopathological evaluation of gallbladder polyps in elderly patients.