Background: Clear Cell Renal Cell Carcinoma (ccRCC) can rarely metastasize to the pancreas, particularly in a multifocal pattern, posing diagnostic and therapeutic challenges.
Clinical case: This case report describes a 67-year-old female with a history of radical nephrectomy in 2014 due to renal cell carcinoma who, after ten years, presented with four pancreatic nodules suspected for metastatic recurrence. A total pancreatectomy was performed, achieving clear margins and negative lymph nodes and the suspicion was confirmed. The postoperative course was favorable.
Conclusion: The literature lacks a defined standard for managing such a situation, but selected patients may benefit from curative surgery. This case highlights the late metastatic potential of ccRCC and supports surgical treatment for specific scenarios.