Postoperative duodenal fistulas are rare but serious complications, most often occurring after abdominal surgery.
They result in major fluid and electrolyte losses, a high risk of sepsis, and delayed wound healing. We report a case of postoperative duodenal fistula illustrating the diagnostic and therapeutic complexity of this condition. Diagnosis is based on the clinical finding of digestive fluid leakage through the surgical wound, and which is confirmed by imaging studies. Management combines drainage, nutritional support, antibiotic therapy, and, in some cases, surgical intervention. Recent advances, particularly enteral nutrition and the use of somatostatin, have significantly reduced mortality. A multidisciplinary approach remains essential to improve patient outcomes.