2025, Vol. 7, Issue 2, Part D
Neoadjuvant chemotherapy in uterine carcinosarcoma: A case report of a complete remission of the epithelial component and successful surgical management
Author(s): Chrigui Maha, Jouini Safa, Bouida Amine, Bouaziz Hanen, Jaidane Olfa and Ben Dhiab Tarek
Abstract: Introduction and importance: Uterine carcinosarcomas are rare tumors that account for less than 5% of all uterine malignancies. Surgery remains the mainstay of treatment for early-stage disease, and there is no consensus on a standard regimen of chemotherapy.
Case presentation: We report the case of a 22-year-old woman who presented with vaginal bleeding. An initial excision revealed a benign lesion. Nine months later, she presented with the same symptoms. Examination under general anesthesia revealed a friable mass filling the vaginal cavity, originating from the cervix, while the vaginal walls and parametrium were intact. Pelvic MRI showed a solid-cystic mass in the uterine cavity. Histopathology confirmed a sarcomatous component with rhabdomyoblastic differentiation. A multidisciplinary team recommended neoadjuvant chemotherapy, resulting in tumor shrinkage from 100 mm to 25 × 48 mm. The patient subsequently underwent an interadnexal hysterectomy, pelvic dissection, lombo-aortic lymph node sampling, and ovarian transposition. The postoperative course was uneventful. She received adjuvant chemotherapy, followed by concomitant chemoradiotherapy. Follow-up was conducted quarterly, and as of her last clinical and radiological assessment in March 2025, there was no evidence of recurrence.
Clinical discussion: Uterine carcinosarcomas are aggressive tumors with both carcinomatous and sarcomatous components. MRI is essential for diagnosis and staging. Neoadjuvant chemotherapy may reduce tumor burden, but sarcomatous elements often show limited response.
Conclusion: Chemotherapy can contribute to tumor control but may be less effective on the sarcomatous component.
DOI: 10.22271/27081494.2025.v7.i2d.227Pages: 251-255 | Views: 205 | Downloads: 65Download Full Article: Click Here
How to cite this article:
Chrigui Maha, Jouini Safa, Bouida Amine, Bouaziz Hanen, Jaidane Olfa, Ben Dhiab Tarek.
Neoadjuvant chemotherapy in uterine carcinosarcoma: A case report of a complete remission of the epithelial component and successful surgical management. Int J Case Rep Surg 2025;7(2):251-255. DOI:
10.22271/27081494.2025.v7.i2d.227
