Surgical Resection of a 68-lbs Retroperitoneal Myxoid Liposarcoma
Author(s): Zvi H Perry, Yael Amozeg, Uri Netz, Michael Rivin and Itzhak Avital
Abstract: Liposarcoma is a malignant soft tissue tumor, with myxoid liposarcoma representing a distinct subtype characterized by a chromosomal translocation between chromosomes 12 and 16. Retroperitoneal myxoid liposarcomas are rare, often asymptomatic until they reach substantial size due to deep anatomical location. We report a case of a 41-year-old male with a prior history of high-grade myxoid liposarcoma of the knee, who presented with abdominal fullness, pain, and cachexia. Imaging revealed a massive retroperitoneal tumor. Surgical intervention involved complete tumor excision, right colectomy, and partial small bowel resection due to ischemia. The excised tumor weighed 68.1 lbs, one of the largest retroperitoneal liposarcomas reported. Pathology confirmed myxoid liposarcoma with negative margins. Despite successful surgery and recovery, the patient declined adjuvant chemotherapy and died eight months later.
Zvi H Perry, Yael Amozeg, Uri Netz, Michael Rivin, Itzhak Avital. Surgical Resection of a 68-lbs Retroperitoneal Myxoid Liposarcoma. Int J Case Rep Surg 2025;7(2):174-176. DOI: 10.22271/27081494.2025.v7.i2c.218